Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states

Derek LeRoith, Martin Adamo, Haim Werner, Charles T. Roberts

Resultado de la investigación: Review articlerevisión exhaustiva

107 Citas (Scopus)

Resumen

Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.

Idioma originalEnglish (US)
Páginas (desde-hasta)134-139
Número de páginas6
PublicaciónTrends in Endocrinology and Metabolism
Volumen2
N.º4
DOI
EstadoPublished - 1991
Publicado de forma externa

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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