TY - JOUR
T1 - Instrumental validation of free water, peak-width of skeletonized mean diffusivity, and white matter hyperintensities
T2 - MarkVCID neuroimaging kits
AU - for the MarkVCID Consortium
AU - Maillard, Pauline
AU - Lu, Hanzhang
AU - Arfanakis, Konstantinos
AU - Gold, Brian T.
AU - Bauer, Christopher E.
AU - Zachariou, Valentinos
AU - Stables, Lara
AU - Wang, Danny J.J.
AU - Jann, Kay
AU - Seshadri, Sudha
AU - Duering, Marco
AU - Hillmer, Laura J.
AU - Rosenberg, Gary A.
AU - Snoussi, Haykel
AU - Sepehrband, Farshid
AU - Habes, Mohamad
AU - Singh, Baljeet
AU - Kramer, Joel H.
AU - Corriveau, Roderick A.
AU - Singh, Herpreet
AU - Schwab, Kristin
AU - Helmer, Karl G.
AU - Greenberg, Steven M.
AU - Caprihan, Arvind
AU - DeCarli, Charles
AU - Satizabal, Claudia L.
N1 - Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
PY - 2022
Y1 - 2022
N2 - Introduction: To describe the protocol and findings of the instrumental validation of three imaging-based biomarker kits selected by the MarkVCID consortium: free water (FW) and peak width of skeletonized mean diffusivity (PSMD), both derived from diffusion tensor imaging (DTI), and white matter hyperintensity (WMH) volume derived from fluid attenuation inversion recovery and T1-weighted imaging. Methods: The instrumental validation of imaging-based biomarker kits included inter-rater reliability among participating sites, test–retest repeatability, and inter-scanner reproducibility across three types of magnetic resonance imaging (MRI) scanners using intra-class correlation coefficients (ICC). Results: The three biomarkers demonstrated excellent inter-rater reliability (ICC >0.94, P-values <.001), very high agreement between test and retest sessions (ICC >0.98, P-values <.001), and were extremely consistent across the three scanners (ICC >0.98, P-values <.001). Discussion: The three biomarker kits demonstrated very high inter-rater reliability, test–retest repeatability, and inter-scanner reproducibility, offering robust biomarkers suitable for future multi-site observational studies and clinical trials in the context of vascular cognitive impairment and dementia (VCID).
AB - Introduction: To describe the protocol and findings of the instrumental validation of three imaging-based biomarker kits selected by the MarkVCID consortium: free water (FW) and peak width of skeletonized mean diffusivity (PSMD), both derived from diffusion tensor imaging (DTI), and white matter hyperintensity (WMH) volume derived from fluid attenuation inversion recovery and T1-weighted imaging. Methods: The instrumental validation of imaging-based biomarker kits included inter-rater reliability among participating sites, test–retest repeatability, and inter-scanner reproducibility across three types of magnetic resonance imaging (MRI) scanners using intra-class correlation coefficients (ICC). Results: The three biomarkers demonstrated excellent inter-rater reliability (ICC >0.94, P-values <.001), very high agreement between test and retest sessions (ICC >0.98, P-values <.001), and were extremely consistent across the three scanners (ICC >0.98, P-values <.001). Discussion: The three biomarker kits demonstrated very high inter-rater reliability, test–retest repeatability, and inter-scanner reproducibility, offering robust biomarkers suitable for future multi-site observational studies and clinical trials in the context of vascular cognitive impairment and dementia (VCID).
KW - VCID
KW - biomarker
KW - diffusion tensor imaging
KW - free water
KW - magnetic resonance imaging
KW - peak-width skeletonized mean diffusivity
KW - small vessel disease
KW - vascular contributions to cognitive impairment and dementia
KW - white matter hyperintensity
KW - white matter injury
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U2 - 10.1002/dad2.12261
DO - 10.1002/dad2.12261
M3 - Article
C2 - 35382232
AN - SCOPUS:85140455111
SN - 2352-8729
VL - 14
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 1
M1 - e12261
ER -