Inspiratory limb carbon dioxide entrainment during high-frequency oscillatory ventilation: Characterization in a mechanical test lung and swine model

Adam W. Bostick, Gregory A. Naworol, Tyler J. Britton, Timothy R. Ori, Shawn K. French, Stephen Derdak

Resultado de la investigación: Articlerevisión exhaustiva

6 Citas (Scopus)


BACKGROUND: High-frequency oscillatory ventilation (HFOV) has been utilized as a rescue oxygenation therapy in adults with ARDS over the last decade. The HFOV oscillating piston can generate negative pressure during the exhalation cycle, which has been termed active exhalation. We hypothesized that this characteristic of HFOV entrains CO2 into the inspiratory limb of the circuit and increases the total dead space. The purpose of this study was to determine if retrograde CO2 entrainment occurs and how it is altered by HFOV parameter settings. METHODS: An HFOV was interfaced to a cuffed endotracheal tube and connected to a mechanical test lung. Negative pressure changes within the circuit's inspiratory limb were measured while HFOV settings were manipulated. Retrograde CO2 entrainment was evaluated by insufflating CO2 into the test lung to achieve 40 mm Hg at the carina. Inspiratory limb CO2 entrainment was measured at incremental distances from the Y-piece. HFOV settings and cuff leak were varied to assess their effect on CO2 entrainment. Control experiments were conducted using a conventional ventilator. Test lung results were validated on a large hypercapnic swine. RESULTS: Negative pressure was detectable within the inspiratory limb of the HFOV circuit and varied inversely with mean airway pressure (Paw) and directly with oscillatory pressure amplitude (ΔP). CO2 was readily detectable within the inspiratory limb and was proportional to the negative pressure that was generated. Factors that decreased CO2 entrainment in both the test lung and swine included low ΔP, high mean airway pressure, high oscillatory frequency (Hz), high bias flow, and endotracheal tube cuff leak placement. CO2 entrainment was also reduced by utilizing a higher bias flow strategy at any targeted mean airway pressure. CONCLUSIONS: Retrograde CO2 entrainment occurs during HFOV use and can be manipulated with the ventilator settings. This phenomenon may have clinical implications on the development or persistence of hypercapnia.

Idioma originalEnglish (US)
Páginas (desde-hasta)1865-1872
Número de páginas8
PublicaciónRespiratory care
EstadoPublished - nov 2012
Publicado de forma externa

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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