@article{ebf441b6d6af42539a9f4c68760157d7,
title = "Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype",
abstract = "Introduction: We evaluated whether insomnia symptom severity was associated with cognitive function, and whether this relationship was modified by biomarkers associated with Alzheimer's disease risk. Methods: We examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia-free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male). Additionally, we explored insomnia symptoms combined with self-reported short habitual sleep duration and effect modification by apolipoprotein E (APOE) ε4 allele status. Results: More severe insomnia symptoms were associated with lower performance on global cognition, and immediate and delayed Logical Memory recall, especially when insomnia symptoms were combined with short sleep duration. The association between insomnia symptoms and poorer memory recall was more pronounced in APOE ε4 allele carriers. Discussion: Insomnia symptom severity was associated with worse subsequent global cognitive and memory performance, which was especially apparent in APOE ε4 allele carriers, suggesting that poor sleep might be particularly detrimental when the brain is already vulnerable to neurodegeneration.",
keywords = "Alzheimer's disease, C-reactive protein, aging, apolipoprotein E ε4, cognition, cognitive aging, dementia, inflammation, insomnia, memory, neuropsychology, sleep",
author = "Baril, {Andr{\'e}e Ann} and Beiser, {Alexa S.} and Erlan Sanchez and Vincent Mysliwiec and Susan Redline and Gottlieb, {Daniel J.} and O'Connor, {George T.} and Gonzales, {Mitzi M.} and Dibya Himali and Sudha Seshadri and Himali, {Jayandra J.} and Pase, {Matthew P.}",
note = "Funding Information: The authors thank the participants and staff of the Framingham Heart Study and the Sleep Heart Health Study. The Framingham Heart study and Dr. Seshadri are funded by contracts from the National Institutes of Health (N01‐HC‐25195, HHSN268201500001I, 75N92019D00031) and grants from the National Institute on Aging (AG059421, AG054076, AG049607, AG033090, NS017950). The Sleep Heart Health Study was funded by the National Heart, Lung and Blood Institute (UO1 HL 53941). Dr. Baril is funded by the (#260192) and the Canadian Institutes of Health Research (#396130). Dr. Redline is partially supported by funds from the National Heart, Lung and Blood Institute (R35 135818). Dr. Pase is funded by a National Heart Foundation of Australia Future Leader Fellowship (ID 102052), the National Health and Medical Research Council (APP1158384), the Alzheimer's Association (AARG‐18‐591358), and the Bethlehem Griffiths Research Foundation. Dr. Pase and Dr. Himali are also supported by a grant from the National Institute on Aging (AG062531). Fonds de la Recherche du Qu{\'e}bec en Sant{\'e} Funding Information: The authors thank the participants and staff of the Framingham Heart Study and the Sleep Heart Health Study. The Framingham Heart study and Dr. Seshadri are funded by contracts from the National Institutes of Health (N01-HC-25195, HHSN268201500001I, 75N92019D00031) and grants from the National Institute on Aging (AG059421, AG054076, AG049607, AG033090, NS017950). The Sleep Heart Health Study was funded by the National Heart, Lung and Blood Institute (UO1 HL 53941). Dr. Baril is funded by the Fonds de la Recherche du Qu?bec en Sant? (#260192) and the Canadian Institutes of Health Research (#396130). Dr. Redline is partially supported by funds from the National Heart, Lung and Blood Institute (R35 135818). Dr. Pase is funded by a National Heart Foundation of Australia Future Leader Fellowship (ID 102052), the National Health and Medical Research Council (APP1158384), the Alzheimer's Association (AARG-18-591358), and the Bethlehem Griffiths Research Foundation. Dr. Pase and Dr. Himali are also supported by a grant from the National Institute on Aging (AG062531). Publisher Copyright: {\textcopyright} 2021 the Alzheimer's Association.",
year = "2022",
month = mar,
doi = "10.1002/alz.12405",
language = "English (US)",
volume = "18",
pages = "408--421",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "3",
}