Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

Douglas J. Harrison; Jonathan D. Gill; Michael E. Roth; Wendong Zhang; Beverly Teicher; Stephen Erickson; Greg Gatto; Raushan T. Kurmasheva; Peter J. Houghton; Malcolm A. Smith; Edward Anders Kolb; Richard Gorlick

doi:10.1002/pbc.28222

Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

Douglas J. Harrison, Jonathan D. Gill, Michael E. Roth, Wendong Zhang, Beverly Teicher, Stephen Erickson, Greg Gatto, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Edward Anders Kolb, Richard Gorlick

Producción científica: Article › revisión exhaustiva

13 Citas (Scopus)

Resumen

Background: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. Procedures: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. Results: Regorafenib induced modest inhibition of tumor growth in the models evaluated. Conclusion: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.

Idioma original	English (US)
Número de artículo	e28222
Publicación	Pediatric Blood and Cancer
Volumen	67
N.º	6
DOI	https://doi.org/10.1002/pbc.28222
Estado	Published - jun 1 2020

ASJC Scopus subject areas

Hematology
Oncology
Pediatrics, Perinatology, and Child Health

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Harrison, D. J., Gill, J. D., Roth, M. E., Zhang, W., Teicher, B., Erickson, S., Gatto, G., Kurmasheva, R. T., Houghton, P. J., Smith, M. A., Kolb, E. A., & Gorlick, R. (2020). Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium. Pediatric Blood and Cancer, 67(6), Artículo e28222. https://doi.org/10.1002/pbc.28222

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title = "Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium",

abstract = "Background: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. Procedures: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. Results: Regorafenib induced modest inhibition of tumor growth in the models evaluated. Conclusion: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.",

keywords = "Ewing sarcoma, multitarget kinase inhibitor, osteosarcoma, patient derived xenograft, pediatric preclinical testing consortium, rhabdomyosarcoma",

author = "Harrison, {Douglas J.} and Gill, {Jonathan D.} and Roth, {Michael E.} and Wendong Zhang and Beverly Teicher and Stephen Erickson and Greg Gatto and Kurmasheva, {Raushan T.} and Houghton, {Peter J.} and Smith, {Malcolm A.} and Kolb, {Edward Anders} and Richard Gorlick",

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doi = "10.1002/pbc.28222",

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T1 - Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

AU - Harrison, Douglas J.

AU - Gill, Jonathan D.

AU - Roth, Michael E.

AU - Zhang, Wendong

AU - Teicher, Beverly

AU - Erickson, Stephen

AU - Gatto, Greg

AU - Kurmasheva, Raushan T.

AU - Houghton, Peter J.

AU - Smith, Malcolm A.

AU - Kolb, Edward Anders

AU - Gorlick, Richard

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Background: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. Procedures: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. Results: Regorafenib induced modest inhibition of tumor growth in the models evaluated. Conclusion: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.

AB - Background: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. Procedures: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. Results: Regorafenib induced modest inhibition of tumor growth in the models evaluated. Conclusion: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.

KW - Ewing sarcoma

KW - multitarget kinase inhibitor

KW - osteosarcoma

KW - patient derived xenograft

KW - pediatric preclinical testing consortium

KW - rhabdomyosarcoma

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DO - 10.1002/pbc.28222

M3 - Article

C2 - 32207565

AN - SCOPUS:85082815577

SN - 1545-5009

VL - 67

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 6

M1 - e28222

ER -

Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

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