Inhibition of Toll-like receptor 9 attenuates sepsis-induced mortality through suppressing excessive inflammatory response

Dan Hu, Xiaohua Yang, Yanxiao Xiang, Hui Li, Hui Yan, Jun Zhou, Yi Caudle, Xiumei Zhang, Deling Yin

Resultado de la investigación: Articlerevisión exhaustiva

26 Citas (Scopus)

Resumen

Sepsis, a major clinical problem with high morbidity and mortality, is caused by overwhelming systemic host-inflammatory response. Toll-like receptors (TLRs) play a fundamental role in induction of hyperinflammation and tissue damage in sepsis. In this study, we demonstrate a protective role of TLR9 inhibition against the dysregulated inflammatory response and tissue injury in sepsis. TLR9 deficiency decreased the mortality of mice following cecal ligation and puncture (CLP)-induced sepsis. TLR9 knockout mice showed dampened p38 activation and augmented Akt phosphorylation in the spleen, lung and liver. In addition, TLR9 deficiency decreased the levels of inflammatory cytokines and attenuated splenic apoptosis after CLP. These results indicate that TLR9 inhibition might offer a novel therapeutic strategy for the management of sepsis.

Idioma originalEnglish (US)
Páginas (desde-hasta)92-98
Número de páginas7
PublicaciónCellular Immunology
Volumen295
N.º2
DOI
EstadoPublished - jun. 1 2015
Publicado de forma externa

ASJC Scopus subject areas

  • Immunology

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