Inhibition of human chorionic gonadotrophin induced hypertrophy of the ovaries and uterus in immature mice by some pineal indoles, 6 hydroxymelatonin and arginine vasotocin

Administration of the indoles 5 methoxytryptophol, 6 hydroxymelatonin, melatonin N acetylserotonin or 5 methoxyindole 3 acetic acid (six 100 μg injections given at intervals of 12 h) inhibited both the absolute and relative ovarian and uterine weights of immature female mice pre treated with HCG. Administration of 5 hydroxytryptophol or 5 methoxytryptamine at the same dosage inhibited ovarian but not uterine hypertrophy in mice pre treated with HCG.