Inhibition of host cell cytokinesis by Chlamydia trachomatis infection

Whitney Greene, Guangming Zhong

Resultado de la investigación: Articlerevisión exhaustiva

38 Citas (Scopus)

Resumen

Objectives. Chlamydia has to replicate in cytoplasmic vacuoles of eukaryotic cells. To understand how chlamydia interacts with host cells during cell division, we examined the effect of chlamydial infection on host cell cycle. Methods. An immunofluorescence microscopic approach was used. Results. Although the number of cells was significantly reduced in chlamydia-infected cultures, multiple nuclei were detected in the infected cells, indicating that chlamydia inhibited host cell growth by selectively blocking cytokinesis while allowing mitosis to proceed. The chlamydial inhibition of host cell cytokinesis was confirmed with various strains of Chlamydia trachomatis and in several types of host cells. Furthermore, the chlamydial inhibitory effect was found to depend on chlamydial protein synthesis. Discussions. These observations suggest that chlamydia may have evolved specific mechanisms for actively blocking hot cell cytokinesis.

Idioma originalEnglish (US)
Páginas (desde-hasta)45-51
Número de páginas7
PublicaciónJournal of Infection
Volumen47
N.º1
DOI
EstadoPublished - jul. 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Huella

Profundice en los temas de investigación de 'Inhibition of host cell cytokinesis by Chlamydia trachomatis infection'. En conjunto forman una huella única.

Citar esto