Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

R. Karthikeyan; S. Karthigayan; M. Sri Balasubashini; S. Vijayalakshmi; S. T. Somasundaram; T. Balasubramanian

doi:10.3923/ijcr.2007.186.190

Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

R. Karthikeyan
, S. Karthigayan
, M. Sri Balasubashini
, S. Vijayalakshmi
, S. T. Somasundaram
, T. Balasubramanian

Producción científica: Article › revisión exhaustiva

5 Citas (Scopus)

Resumen

The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL^-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

Idioma original	English (US)
Páginas (desde-hasta)	186-190
Número de páginas	5
Publicación	International Journal of Cancer Research
Volumen	3
N.º	4
DOI	https://doi.org/10.3923/ijcr.2007.186.190
Estado	Published - 2007
Publicado de forma externa	Sí

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom",

abstract = "The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81\%.",

keywords = "Antitumor, Cell line, Ehrlich's ascites carcinoma, Hydrophis spiralis, Sea snake venom",

author = "R. Karthikeyan and S. Karthigayan and \{Sri Balasubashini\}, M. and S. Vijayalakshmi and Somasundaram, \{S. T.\} and T. Balasubramanian",

year = "2007",

doi = "10.3923/ijcr.2007.186.190",

language = "English (US)",

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journal = "International Journal of Cancer Research",

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T1 - Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

AU - Karthikeyan, R.

AU - Karthigayan, S.

AU - Sri Balasubashini, M.

AU - Vijayalakshmi, S.

AU - Somasundaram, S. T.

AU - Balasubramanian, T.

PY - 2007

Y1 - 2007

N2 - The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

AB - The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

KW - Antitumor

KW - Cell line

KW - Ehrlich's ascites carcinoma

KW - Hydrophis spiralis

KW - Sea snake venom

UR - https://www.scopus.com/pages/publications/35348977763

UR - https://www.scopus.com/pages/publications/35348977763#tab=citedBy

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DO - 10.3923/ijcr.2007.186.190

M3 - Article

AN - SCOPUS:35348977763

SN - 1811-9727

VL - 3

SP - 186

EP - 190

JO - International Journal of Cancer Research

JF - International Journal of Cancer Research

IS - 4

ER -

Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

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