Influence of surgical approach on cancer control following radical prostatectomy

Rhonda Cornum, Samuel J. Peretsman, Ian M. Thompson

Resultado de la investigación: Articlerevisión exhaustiva

3 Citas (Scopus)


Pathologic T3 prostate cancer (extraprostatic spread) detected following radical prostatectomy reduces the likelihood of cure. We conducted this study to determine the impact of the surgical approach (retropubic versus perineal) on risk and location of pT3 disease. A retrospective analysis of 287 consecutive radical prostatectomies [III retropubic (RRP) and 176 perineal (RPP)] was conducted. Specimens were pathologically examined for presence or absence of pT3 disease. A greater rate of pT3 disease was found with RRP than with RPP, which was likely due to patient selection. Of specimens with a single positive surgical margin, the positive margin was more common at the base of the gland with RPP than with RRP (38.5% versus 9.3%). Conversely, the percentage of specimens with a positive apical margin only was less with RPP than with RRP (12.8% versus 44.2%) (Chi-square, p ≤0.025). These results lead us to conclude that RPP may achieve superior cancer control for tumors located at the prostate apex, while the retropubic approach may be preferred for tumors located at the prostatic base.

Idioma originalEnglish (US)
Páginas (desde-hasta)198-201
Número de páginas4
PublicaciónUrologic Oncology
EstadoPublished - 1996
Publicado de forma externa

ASJC Scopus subject areas

  • Oncology
  • Urology


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