Influence of serum and albumin on echinocandin in vitro potency and pharmacodynamics

Aasya Nasar, Laurajo Ryan, Christopher R. Frei, Jason M. Cota, Nathan P. Wiederhold

Producción científica: Articlerevisión exhaustiva

11 Citas (Scopus)

Resumen

The echinocandins target fungi by inhibiting the production of (1,3)-β-d-glucan, an essential component of the fungal cell wall. These agents have less toxicity to mammalian cells, as compared to other antifungals; however, they maintain potent activity against many pathogenic fungi, including polyene- and azole-resistant isolates. Members of this class are highly protein-bound, and the addition of serum or albumin to the growth medium has profound effects on their in vitro potency and pharmacodynamics. In addition, studies have demonstrated an association between in vitro activity, in the presence of serum, and outcomes in animal models of invasive fungal infections. Serum and albumin may also be useful to help detect echinocandin-resistant Candida isolates with point mutations in the gene that encodes for glucan synthase. Thus, in vitro studies evaluating echinocandins in the presence of protein can provide valuable insight regarding their potency and pharmacodynamics.

Idioma originalEnglish (US)
Páginas (desde-hasta)89-95
Número de páginas7
PublicaciónCurrent Fungal Infection Reports
Volumen7
N.º2
DOI
EstadoPublished - jun 2013

ASJC Scopus subject areas

  • Infectious Diseases

Huella

Profundice en los temas de investigación de 'Influence of serum and albumin on echinocandin in vitro potency and pharmacodynamics'. En conjunto forman una huella única.

Citar esto