Influence of pregnancy on the hepatic metabolism of parathion

S. D. Weitman, M. J. Vodicnik, J. J. Lech

Resultado de la investigación: Articlerevisión exhaustiva

2 Citas (Scopus)

Resumen

The effect of pregnancy on the hepatic metabolism of parathion was examined. The in vitro rate of hepatic microsomal activation of parathion to paraoxon was significantly reduced in mice at 19 days of gestation when compared to nonpregnant controls. Total hepatic metabolism of parathion was determined during in situ perfusion of livers from pregnant and nonpregnant mice. Levels of parathion, paraoxon, and p-nitrophenol in the perfusate after 45 min of perfusion did not differ significantly between livers from the pregnant and nonpregnant groups. These data indicate that total hepatic metabolism of these three compounds is not altered in pregnancy despite a decrease in specific activity for parathion activation.

Idioma originalEnglish (US)
Páginas (desde-hasta)23-31
Número de páginas9
PublicaciónDevelopmental Pharmacology and Therapeutics
Volumen9
N.º1
DOI
EstadoPublished - 1986
Publicado de forma externa

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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