Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia

Meryl S. Cohen, Jack Rychik, David M. Bush, Zhi Yun Tian, Lori J. Howell, N. Scott Adzick, Alan W. Flake, Mark P. Johnson, Thomas L. Spray, Timothy M. Crombleholme

Resultado de la investigación: Articlerevisión exhaustiva

96 Citas (Scopus)


Objective: We sought to assess outcome in patients with CDH and HD to determine if LHR is also predictive of outcome in this subset of patients. Study design: We carried out a retrospective review (April 1996-October 2000) of patients with isolated CDH (n = 143, 82.2%) and patients with HD (n = 31, 17.8%) to determine the incidence of additional anomalies, survival to term, CDH repair, cardiac repair, and survival to discharge. Survival based on LHR was analyzed in a subset of fetuses. Results: The risk of death from birth to last follow-up was 2.9 times higher for patients with CDH plus HD than for patients with CDH alone (P < .0001). Of 11 patients with CDH plus HD who had CDH repair (5 of whom also had HD repair), 5 survived. All 10 patients with an LHR < 1.2 died; 3 of 6 with an LHR > 1.2 survived (Fisher exact test, P = .04). Conclusion: Heart disease remains a significant risk factor for death in infants with CDH. The LHR helps predict survival in this high-risk group of patients.

Idioma originalEnglish (US)
Páginas (desde-hasta)25-30
Número de páginas6
PublicaciónJournal of Pediatrics
EstadoPublished - 2002
Publicado de forma externa

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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