TY - JOUR
T1 - Influence of anxiety/depression on chemotherapy-induced oral mucositis and related quality of life
T2 - A prospective cohort study
AU - de Arruda, José Alcides Almeida
AU - Heimlich, Fernanda Vieira
AU - Oliveira, Sicília Rezende
AU - Drumond, Victor Zanetti
AU - Travassos, Denise Vieira
AU - Abreu, Lucas Guimarães
AU - Teixeira, Antonio Lucio
AU - Mesquita, Ricardo Alves
AU - Silva, Tarcília Aparecida
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2024/2
Y1 - 2024/2
N2 - Objective: The impact of anxiety and depression on chemotherapy-induced oral mucositis has not been extensively explored in the literature. The aim of the present study was to evaluate anxiety/depressive symptoms, health-related quality of life, and oral health-related quality of life and their association with oral mucositis among individuals receiving chemotherapy. Methods: This is a prospective longitudinal study carried out at a Brazilian referral service. The Hospital Anxiety and Depression Scale (HADS), World Health Organization Quality of Life-BREF (WHOQOL-BREF), and Oral Health Impact Profile questionnaire (OHIP-14) were applied at D0 (before chemotherapy) and D15 of chemotherapy. Clinicodemographic data and oral mucositis severity scores were evaluated. Results: A total of 37 individuals (median age: 49 years) were included in the study. Nearly 38% of patients developed chemotherapy-induced oral mucositis and had higher anxiety/depression scores at baseline. Oral mucositis had a negative impact on oral health-related quality of life regarding functional limitation, physical pain, physical disability, and handicap. Conclusion: Anxiety/depressive symptoms are associated with oral mucositis that affects overall health and oral health-related quality of life.
AB - Objective: The impact of anxiety and depression on chemotherapy-induced oral mucositis has not been extensively explored in the literature. The aim of the present study was to evaluate anxiety/depressive symptoms, health-related quality of life, and oral health-related quality of life and their association with oral mucositis among individuals receiving chemotherapy. Methods: This is a prospective longitudinal study carried out at a Brazilian referral service. The Hospital Anxiety and Depression Scale (HADS), World Health Organization Quality of Life-BREF (WHOQOL-BREF), and Oral Health Impact Profile questionnaire (OHIP-14) were applied at D0 (before chemotherapy) and D15 of chemotherapy. Clinicodemographic data and oral mucositis severity scores were evaluated. Results: A total of 37 individuals (median age: 49 years) were included in the study. Nearly 38% of patients developed chemotherapy-induced oral mucositis and had higher anxiety/depression scores at baseline. Oral mucositis had a negative impact on oral health-related quality of life regarding functional limitation, physical pain, physical disability, and handicap. Conclusion: Anxiety/depressive symptoms are associated with oral mucositis that affects overall health and oral health-related quality of life.
KW - Anxiety
KW - Chemotherapy
KW - Depression
KW - Oncology
KW - Oral mucositis
KW - Quality of life
UR - https://www.scopus.com/pages/publications/85181110890
UR - https://www.scopus.com/pages/publications/85181110890#tab=citedBy
U2 - 10.1016/j.jpsychores.2023.111577
DO - 10.1016/j.jpsychores.2023.111577
M3 - Article
C2 - 38154442
AN - SCOPUS:85181110890
SN - 0022-3999
VL - 177
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
M1 - 111577
ER -