Influence of anxiety/depression on chemotherapy-induced oral mucositis and related quality of life: A prospective cohort study

José Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Sicília Rezende Oliveira, Victor Zanetti Drumond, Denise Vieira Travassos, Lucas Guimarães Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcília Aparecida Silva

Producción científica: Articlerevisión exhaustiva

Resumen

Objective: The impact of anxiety and depression on chemotherapy-induced oral mucositis has not been extensively explored in the literature. The aim of the present study was to evaluate anxiety/depressive symptoms, health-related quality of life, and oral health-related quality of life and their association with oral mucositis among individuals receiving chemotherapy. Methods: This is a prospective longitudinal study carried out at a Brazilian referral service. The Hospital Anxiety and Depression Scale (HADS), World Health Organization Quality of Life-BREF (WHOQOL-BREF), and Oral Health Impact Profile questionnaire (OHIP-14) were applied at D0 (before chemotherapy) and D15 of chemotherapy. Clinicodemographic data and oral mucositis severity scores were evaluated. Results: A total of 37 individuals (median age: 49 years) were included in the study. Nearly 38% of patients developed chemotherapy-induced oral mucositis and had higher anxiety/depression scores at baseline. Oral mucositis had a negative impact on oral health-related quality of life regarding functional limitation, physical pain, physical disability, and handicap. Conclusion: Anxiety/depressive symptoms are associated with oral mucositis that affects overall health and oral health-related quality of life.

Idioma originalEnglish (US)
Número de artículo111577
PublicaciónJournal of Psychosomatic Research
Volumen177
DOI
EstadoPublished - feb 2024
Publicado de forma externa

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

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