TY - JOUR
T1 - Inflammatory proteins and the severity of dilated Virchow-Robin spaces in the elderly
AU - Satizabal, Claudia L.
AU - Zhu, Yi Cheng
AU - Dufouil, Carole
AU - Tzourio, Christophe
PY - 2013
Y1 - 2013
N2 - Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.
AB - Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.
KW - Aged
KW - cerebral small vessel diseases
KW - dilated Virchow-Robin spaces
KW - inflammation
KW - magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=84872459539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872459539&partnerID=8YFLogxK
U2 - 10.3233/JAD-2012-120874
DO - 10.3233/JAD-2012-120874
M3 - Article
C2 - 22976070
AN - SCOPUS:84872459539
SN - 1387-2877
VL - 33
SP - 323
EP - 328
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -