TY - JOUR
T1 - Inflammatory myofibroblastic tumor of the lung
AU - Khatri, Akshay
AU - Agrawal, Abhinav
AU - Sikachi, Rutuja R.
AU - Mehta, Dhruv
AU - Sahni, Sonu
AU - Meena, Nikhil
N1 - Publisher Copyright:
© 2018 PTChP.
PY - 2018/2/28
Y1 - 2018/2/28
N2 - Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo -tumors. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils. IMTs may be benign, invade surrounding structures, undergo malignant transformation, recur or may even metastasize. They can occur due to a genetic mutation or can occur secondary to infectious or autoimmune diseases. Patients may be asymptomatic, or present with cough, hemoptysis, dyspnea, pleuritic pain, constitutional symptoms or pneumonia. In this article we review the pathophysiology, genetics, clinical presentation, imaging findings of IMT of the lung. We also discuss the various surgical and non-surgical treatment options and the prognosis associated with this disease.
AB - Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo -tumors. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils. IMTs may be benign, invade surrounding structures, undergo malignant transformation, recur or may even metastasize. They can occur due to a genetic mutation or can occur secondary to infectious or autoimmune diseases. Patients may be asymptomatic, or present with cough, hemoptysis, dyspnea, pleuritic pain, constitutional symptoms or pneumonia. In this article we review the pathophysiology, genetics, clinical presentation, imaging findings of IMT of the lung. We also discuss the various surgical and non-surgical treatment options and the prognosis associated with this disease.
KW - ALK
KW - Bronchoscopy
KW - Inflammatory myofibroblastic tumor of the lung (IMT)
KW - Inflammatory pseudo-tumor (IPT)
KW - Pulmonary neoplasm
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U2 - 10.5603/ARM.2018.0007
DO - 10.5603/ARM.2018.0007
M3 - Review article
C2 - 29490419
AN - SCOPUS:85044123430
SN - 2451-4934
VL - 86
SP - 27
EP - 35
JO - Advances in Respiratory Medicine
JF - Advances in Respiratory Medicine
IS - 1
ER -