Inflammatory markers and the risk of Alzheimer disease: The Framingham study

Z. S. Tan, A. S. Beiser, R. S. Vasan, R. Roubenoff, C. A. Dinarello, T. B. Harris, E. J. Benjamin, R. Au, D. P. Kiel, P. A. Wolf, S. Seshadri

Producción científica: Articlerevisión exhaustiva

404 Citas (Scopus)

Resumen

OBJECTIVE: To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD). METHODS: We followed 691 cognitively intact community-dwelling participants (mean age 79 years, 62% women) and related PBMC cytokine production (tertiles of spontaneous production of interleukin 1 [IL-1], IL-1 receptor antagonist, and tumor necrosis factor α [TNF-α]) and serum C-reactive protein and interleukin 6 (IL-6) to the risk of incident AD. RESULTS: Adjusting for clinical covariates, individuals in the top two tertiles (T2 and T3) of PBMC production of IL-1 or the top tertile (T3) of PBMC production of TNF-α were at increased risk of developing AD (multivariable-adjusted hazard ratio [HR] for IL-1 T2 = 2.84, 95% CI 1.09 to 7.43; p = 0.03 and T3 = 2.61, 95% CI 0.96 to 7.07; p = 0.06; for TNF-α, adjusted HR for T2 = 1.30, 95% CI 0.53 to 3.17; p = 0.57 and T3 = 2.59, 95% CI 1.09 to 6.12; p = 0.031]) compared with those in the lowest tertile (T1). INTERPRETATION: Higher spontaneous production of interleukin 1 or tumor necrosis factor α by peripheral blood mononuclear cells may be a marker of future risk of Alzheimer disease (AD) in older individuals. These data strengthen the evidence for a pathophysiologic role of inflammation in the development of clinical AD.

Idioma originalEnglish (US)
Páginas (desde-hasta)1902-1908
Número de páginas7
PublicaciónNeurology
Volumen68
N.º22
DOI
EstadoPublished - may 2007
Publicado de forma externa

ASJC Scopus subject areas

  • Clinical Neurology

Huella

Profundice en los temas de investigación de 'Inflammatory markers and the risk of Alzheimer disease: The Framingham study'. En conjunto forman una huella única.

Citar esto