Inflammatory and functional effects of increasing asthma treatment with formoterol or double dose budesonide

Marcelo B. Menezes, Antônio L. Teixeira, João Terra Filho, Elcio O. Vianna

Producción científica: Articlerevisión exhaustiva

6 Citas (Scopus)

Resumen

Adding a long-acting β2-agonist to inhaled corticosteroids (ICS) for asthma treatment is better than increasing ICS dose in improving clinical status, although there is no consensus about the impact of this regimen on inflammation. In this double-blind, randomized, parallel group study, asthmatics with moderate to severe disease used budesonide (400 mcg/day) for 5 weeks (run-in period); then they were randomized to use budesonide (800 mcg/day - BUD group) or budesonide plus formoterol (400 mcg and 24 mcg/day, respectively - FORMO group) for 9 weeks (treatment period). Home PEF measurements, symptom daily reporting, spirometry, sputum induction (for differential cell counts and sputum cell cultures), and hypertonic saline bronchial challenge test were performed before and after treatments. TNF-α, IL-4 and eotaxin-2 levels in the sputum and cell culture supernatants were determined. Morning and night PEF values increased in the FORMO group during the treatment period (p < 0.01), from 435 ± 162 to 489 ± 169 and 428 ± 160 to 496 ± 173 L/min, respectively. The rate of exacerbations in the FORMO group was lower than in the BUD group (p < 0.05). Neutrophil counts in sputum increased in both groups (p < 0.05) and leukocyte viability after 48 h-culture increased in the FORMO group (p < 0.05). No other parameter changed significantly in either group. This study showed that adding formoterol to budesonide improved home PEF and provided protection from exacerbations, although increase of leukocyte viability in cell culture may be a matter of concern and needs further investigation.

Idioma originalEnglish (US)
Páginas (desde-hasta)1385-1391
Número de páginas7
PublicaciónRespiratory Medicine
Volumen102
N.º10
DOI
EstadoPublished - oct 2008
Publicado de forma externa

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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