Inflammasomes: Sensors of metabolic stresses for vascular inflammation

Ying Yin, Jahaira Lopez Pastrana, Xinyuan Li, Xiao Huang, Karthik Mallilankaraman, Eric T. Choi, Muniswamy Madesh, Hong Wang, Xiao Feng Yang

Producción científica: Review articlerevisión exhaustiva

119 Citas (Scopus)

Resumen

Metabolic syndrome is a major health issue in the western world. An elevated pro-inflammatory state is often found in patients with metabolic diseases such as type 2 diabetes and obesity. Atherosclerosis is one such clinical manifestation of pro-inflammatory state associated with the vasculature. The exact mechanism by which metabolic stress induces this pro-inflammatory status and promotes atherogenesis remained elusive until the discovery of the inflammasome protein complex. This complex is composed of pro-caspase-1 and pathogen sensors. Activation of inflammasome requires the transcriptional upregulation of inflammasome components and the post-translational assembly. Three models of inflammasome assembly have been proposed: 1) the ion channel model; 2) the reactive oxygen species (ROS) model; and 3) the lysosome model. In either case, inflammasome activation triggers the autoactivation of pro-caspase-1 into its mature form. Caspase-1, which was first discovered as the IL-1β converting enzyme, is known to be a major player in inflammatory and cell death pathways. Many endogenous metabolic ligands have been experimentally shown to activate inflammasome, and thus initiate the subsequent inflammation process. Further understanding of the distinct molecular mechanism by which metabolic ligands activates inflammasome could lead to developing novel therapeutic interventions for atherosclerosis and other clinical problems related to metabolic diseases.

Idioma originalEnglish (US)
Páginas (desde-hasta)638-649
Número de páginas12
PublicaciónFrontiers in Bioscience
Volumen18
N.º2
DOI
EstadoPublished - ene 1 2013
Publicado de forma externa

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

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