Induction of heat shock proteins in lymphocytes increases with mitogen stimulation

Mahmood Ghassemi, Ahmad R. Heydari, Arlan Richardson

Resultado de la investigación: Articlerevisión exhaustiva

7 Citas (Scopus)

Resumen

The effect of the growth state of a cell on the ability of hyperthermia to induce the synthesis of heat shock proteins (HSPs) was studied in resting and concanavalin A (ConA)-stimulated lymphocytes. Hyperthermia induced the synthesis of hsp 110, hsp 90, hsc 70, and hsp 70 in both resting and ConA-stimulated lymhocytes, and ConA-treatment induced the synthesis of the hsp 90 and hsc 70 at normal temperature. The induction of the synthesis of hsp 110 and hsp 70 by hyperthermia was 3- to 6-fold higher for lymphocytes cultured with ConA for 12 and 24 h than in non-stimulated lymphocytes. Thus, lymphocytes induced to undergo proliferation showed a greater response to hyperthermia than resting lymphocytes.

Idioma originalEnglish (US)
Páginas (desde-hasta)333-337
Número de páginas5
PublicaciónImmunology Letters
Volumen30
N.º3
DOI
EstadoPublished - nov. 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Huella

Profundice en los temas de investigación de 'Induction of heat shock proteins in lymphocytes increases with mitogen stimulation'. En conjunto forman una huella única.

Citar esto