Induction of cell migration of neural progenitor cells in vitro by alpha-1 adrenergic receptor and dopamine D₁ receptor stimulation

The radial migration is an important process in the development of the cerebral cortex. Earlier studies have reported that classical neurotransmitters such as L-dopamine and L-adrenaline regulate the proliferation of neural progenitor cells. We examined whether L-dopamine and L-adrenaline regulate cell migration, using embryonic neural progenitor cells from mouse embryonic telencephalon in vitro. In this study, we showed that dopamine D1 agonist induces cell migration of embryonic neural progenitor cells. In addition, we have demonstrated that L-adrenaline induces cell migration of embryonic neural progenitor cells, mediated through the activation of α-1 adrenergic receptors. Our results suggest that α-1 adrenergic receptor and dopamine D1 receptor stimulations in neural progenitor cells are the important process for embryonic brain development, respectively.