TY - JOUR
T1 - Individual serum saturated fatty acids and markers of chronic subclinical inflammation
T2 - The Insulin Resistance Atherosclerosis Study
AU - Santaren, Ingrid D.
AU - Watkins, Steven M.
AU - Liese, Angela D.
AU - Wagenknecht, Lynne E.
AU - Rewers, Marian J.
AU - Haffner, Steven M.
AU - Lorenzo, Carlos
AU - Festa, Andreas
AU - Bazinet, Richard P.
AU - Hanley, Anthony J.
N1 - Publisher Copyright:
Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.
PY - 2017
Y1 - 2017
N2 - Recent evidence has documented distinct effects of individual saturated FAs (SFAs) on cardiometabolic outcomes, with potential protective effects from odd-and very long-chain SFAs (VLSFAs). Cross-sectional and prospective associations of individual serum SFAs (12:0, 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, and total SFA) with proinflammatory biomarkers and adiponectin were investigated in 555 adults from the IRAS. Principal component analysis (PCA) of proinflammatory markers yielded three clusters: principal component (PC) 1: fibrinogen, white cell count, C-reactive protein; PC 2: plasminogen activator inhibitor-1 (PAI-1), TNF-α, IL-18; PC 3: IL-6 and IL-8. Cross-sectional analyses on proinflammatory PCs and adiponectin, and prospective analyses on 5 year PAI-1 and fibrinogen concentrations were conducted with multiple regression. Total SFA and 16:0 were positively associated with PC 1 and PC 2, and negatively associated with adiponectin. The 14:0 was positively associated with PC 1 and negatively associated with adiponectin. In contrast, 15:0, 20:0, and 22:0 were negatively associated with PC 2, and 20:0 and 22:0 were positively associated with adiponectin. The 18:0 was negatively associated with PC 3. Prospectively, 15:0, 18:0, 20:0, and 22:0 were negatively associated with 5 year PAI-1 concentrations. The results demonstrate that individual SFAs have distinct roles in subclinical in-flammation, highlighting the unique metabolic impacts of individual SFAs.
AB - Recent evidence has documented distinct effects of individual saturated FAs (SFAs) on cardiometabolic outcomes, with potential protective effects from odd-and very long-chain SFAs (VLSFAs). Cross-sectional and prospective associations of individual serum SFAs (12:0, 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, and total SFA) with proinflammatory biomarkers and adiponectin were investigated in 555 adults from the IRAS. Principal component analysis (PCA) of proinflammatory markers yielded three clusters: principal component (PC) 1: fibrinogen, white cell count, C-reactive protein; PC 2: plasminogen activator inhibitor-1 (PAI-1), TNF-α, IL-18; PC 3: IL-6 and IL-8. Cross-sectional analyses on proinflammatory PCs and adiponectin, and prospective analyses on 5 year PAI-1 and fibrinogen concentrations were conducted with multiple regression. Total SFA and 16:0 were positively associated with PC 1 and PC 2, and negatively associated with adiponectin. The 14:0 was positively associated with PC 1 and negatively associated with adiponectin. In contrast, 15:0, 20:0, and 22:0 were negatively associated with PC 2, and 20:0 and 22:0 were positively associated with adiponectin. The 18:0 was negatively associated with PC 3. Prospectively, 15:0, 18:0, 20:0, and 22:0 were negatively associated with 5 year PAI-1 concentrations. The results demonstrate that individual SFAs have distinct roles in subclinical in-flammation, highlighting the unique metabolic impacts of individual SFAs.
KW - Cohort study
KW - Diet and dietary lipids
KW - Epidemiology
KW - Metabolic disease
UR - http://www.scopus.com/inward/record.url?scp=85033570083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033570083&partnerID=8YFLogxK
U2 - 10.1194/jlr.P076836
DO - 10.1194/jlr.P076836
M3 - Article
C2 - 28928169
AN - SCOPUS:85033570083
SN - 0022-2275
VL - 58
SP - 2171
EP - 2179
JO - Journal of lipid research
JF - Journal of lipid research
IS - 11
ER -