TY - JOUR
T1 - Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia
AU - Reis, Helton José
AU - Nicolato, Rodrigo
AU - Barbosa, Izabela Guimarães
AU - Prado, Paulo Henrique Teixeira do
AU - Romano-Silva, Marco Aurélio
AU - Teixeira, Antonio Lucio
PY - 2008/7/11
Y1 - 2008/7/11
N2 - There is a growing body of evidence implicating the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathogenesis of schizophrenia. As circulating BDNF levels may reflect the BDNF levels in the brain, we assessed serum BDNF in 40 institutionalized schizophrenic patients and 20 healthy controls. Serum BNDF levels were significantly increased in schizophrenic patients when compared to control subjects (p < 0.001). Interestingly, serum BDNF correlated positively with the clinical scores at the negative subscale of the positive and negative syndrome scale (PANSS) (r = 0.41; p < 0.01). Our results confirm the emergent literature on the involvement of BDNF in schizophrenia.
AB - There is a growing body of evidence implicating the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathogenesis of schizophrenia. As circulating BDNF levels may reflect the BDNF levels in the brain, we assessed serum BDNF in 40 institutionalized schizophrenic patients and 20 healthy controls. Serum BNDF levels were significantly increased in schizophrenic patients when compared to control subjects (p < 0.001). Interestingly, serum BDNF correlated positively with the clinical scores at the negative subscale of the positive and negative syndrome scale (PANSS) (r = 0.41; p < 0.01). Our results confirm the emergent literature on the involvement of BDNF in schizophrenia.
KW - BDNF
KW - Negative symptoms
KW - Schizophrenia
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U2 - 10.1016/j.neulet.2008.05.022
DO - 10.1016/j.neulet.2008.05.022
M3 - Article
C2 - 18514407
AN - SCOPUS:44649183920
SN - 0304-3940
VL - 439
SP - 157
EP - 159
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -