Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells

Jae H. Hur, Sepehr Bahadorani, Jacqueline Graniel, Christopher L. Koehler, Matthew Ulgherait, Michael Rera, D. Leanne Jones, David W. Walker

Producción científica: Articlerevisión exhaustiva

37 Citas (Scopus)

Resumen

A functional decline in tissue stem cells and mitochondrial dysfunction have each been linked to aging and multiple aging-associated pathologies. However, the interplay between energy homeostasis, stem cells, and organismal aging remains poorly understood. Here, we report that expression of the single-subunit yeast alternative NADH dehydrogenase, ndi1, in Drosophila intestinal stem and progenitor cells delays the onset of multiple markers of intestinal aging and extends lifespan. In addition, expression of ndi1 in the intestine increases feeding behavior and results in organismal weight gain. Consistent with increased nutrient uptake, flies expressing ndi1 in the digestive tract display a systemic reduction in the activity of AMP-activated protein kinase (AMPK), a key cellular energy sensor. Together, these results demonstrate that ndi1 expression in the intestinal epithelium is an effective strategy to delay tissue and organismal aging.

Idioma originalEnglish (US)
Páginas (desde-hasta)662-681
Número de páginas20
PublicaciónAging
Volumen5
N.º9
DOI
EstadoPublished - 2013
Publicado de forma externa

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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