Resumen
The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.
Idioma original | English (US) |
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Páginas (desde-hasta) | 155-159 |
Número de páginas | 5 |
Publicación | Magnetic Resonance in Medicine |
Volumen | 43 |
N.º | 1 |
DOI | |
Estado | Published - 2000 |
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging