In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Barbara J. Hoeben; David S. Burgess; Jason T. McConville; Laura K. Najvar; Robert L. Talbert; Jay I. Peters; Nathan P. Wiederhold; Bradi L. Frei; John R. Graybill; Rosie Bocanegra; Kirk A. Overhoff; Prapasri Sinswat; Keith P. Johnston; Robert O. Williams

doi:10.1128/AAC.50.4.1552-1554.2006

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Barbara J. Hoeben
, David S. Burgess
, Jason T. McConville
, Laura K. Najvar
, Robert L. Talbert
, Jay I. Peters
, Nathan P. Wiederhold
, Bradi L. Frei
, John R. Graybill
, Rosie Bocanegra
, Kirk A. Overhoff
, Prapasri Sinswat
, Keith P. Johnston
, Robert O. Williams

Producción científica: Article › revisión exhaustiva

47 Citas (Scopus)

Resumen

Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

Idioma original	English (US)
Páginas (desde-hasta)	1552-1554
Número de páginas	3
Publicación	Antimicrobial agents and chemotherapy
Volumen	50
N.º	4
DOI	https://doi.org/10.1128/AAC.50.4.1552-1554.2006
Estado	Published - abr 2006

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Acceder al documento

10.1128/AAC.50.4.1552-1554.2006

Otros archivos y enlaces

Citar esto

Hoeben, B. J., Burgess, D. S., McConville, J. T., Najvar, L. K., Talbert, R. L., Peters, J. I., Wiederhold, N. P., Frei, B. L., Graybill, J. R., Bocanegra, R., Overhoff, K. A., Sinswat, P., Johnston, K. P., & Williams, R. O. (2006). In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis. Antimicrobial agents and chemotherapy, 50(4), 1552-1554. https://doi.org/10.1128/AAC.50.4.1552-1554.2006

Hoeben, BJ, Burgess, DS, McConville, JT, Najvar, LK, Talbert, RL, Peters, JI , Wiederhold, NP, Frei, BL, Graybill, JR, Bocanegra, R, Overhoff, KA, Sinswat, P, Johnston, KP & Williams, RO 2006, 'In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis', Antimicrobial agents and chemotherapy, vol. 50, n.º 4, pp. 1552-1554. https://doi.org/10.1128/AAC.50.4.1552-1554.2006

@article{9de4e0530e2c4e0e82d9bc06772b03fa,

title = "In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis",

abstract = "Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.",

author = "Hoeben, \{Barbara J.\} and Burgess, \{David S.\} and McConville, \{Jason T.\} and Najvar, \{Laura K.\} and Talbert, \{Robert L.\} and Peters, \{Jay I.\} and Wiederhold, \{Nathan P.\} and Frei, \{Bradi L.\} and Graybill, \{John R.\} and Rosie Bocanegra and Overhoff, \{Kirk A.\} and Prapasri Sinswat and Johnston, \{Keith P.\} and Williams, \{Robert O.\}",

year = "2006",

month = apr,

doi = "10.1128/AAC.50.4.1552-1554.2006",

language = "English (US)",

volume = "50",

pages = "1552--1554",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "4",

}

TY - JOUR

T1 - In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

AU - Hoeben, Barbara J.

AU - Burgess, David S.

AU - McConville, Jason T.

AU - Najvar, Laura K.

AU - Talbert, Robert L.

AU - Peters, Jay I.

AU - Wiederhold, Nathan P.

AU - Frei, Bradi L.

AU - Graybill, John R.

AU - Bocanegra, Rosie

AU - Overhoff, Kirk A.

AU - Sinswat, Prapasri

AU - Johnston, Keith P.

AU - Williams, Robert O.

PY - 2006/4

Y1 - 2006/4

N2 - Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

AB - Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

UR - https://www.scopus.com/pages/publications/33645792333

UR - https://www.scopus.com/pages/publications/33645792333#tab=citedBy

U2 - 10.1128/AAC.50.4.1552-1554.2006

DO - 10.1128/AAC.50.4.1552-1554.2006

M3 - Article

C2 - 16569882

AN - SCOPUS:33645792333

SN - 0066-4804

VL - 50

SP - 1552

EP - 1554

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 4

ER -

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Resumen

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto