In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Barbara J. Hoeben; David S. Burgess; Jason T. McConville; Laura K. Najvar; Robert L. Talbert; Jay I. Peters; Nathan P. Wiederhold; Bradi L. Frei; John R. Graybill; Rosie Bocanegra; Kirk A. Overhoff; Prapasri Sinswat; Keith P. Johnston; Robert O. Williams

doi:10.1128/AAC.50.4.1552-1554.2006

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Barbara J. Hoeben, David S. Burgess, Jason T. McConville, Laura K. Najvar, Robert L. Talbert, Jay I. Peters, Nathan P. Wiederhold, Bradi L. Frei, John R. Graybill, Rosie Bocanegra, Kirk A. Overhoff, Prapasri Sinswat, Keith P. Johnston, Robert O. Williams

Resultado de la investigación: Article › revisión exhaustiva

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Resumen

Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

Idioma original	English (US)
Páginas (desde-hasta)	1552-1554
Número de páginas	3
Publicación	Antimicrobial agents and chemotherapy
Volumen	50
N.º	4
DOI	https://doi.org/10.1128/AAC.50.4.1552-1554.2006
Estado	Published - abr 2006

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/AAC.50.4.1552-1554.2006

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Hoeben, B. J., Burgess, D. S., McConville, J. T., Najvar, L. K., Talbert, R. L., Peters, J. I., Wiederhold, N. P., Frei, B. L., Graybill, J. R., Bocanegra, R., Overhoff, K. A., Sinswat, P., Johnston, K. P., & Williams, R. O. (2006). In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis. Antimicrobial agents and chemotherapy, 50(4), 1552-1554. https://doi.org/10.1128/AAC.50.4.1552-1554.2006

Hoeben, BJ, Burgess, DS, McConville, JT, Najvar, LK, Talbert, RL, Peters, JI , Wiederhold, NP, Frei, BL, Graybill, JR, Bocanegra, R, Overhoff, KA, Sinswat, P, Johnston, KP & Williams, RO 2006, 'In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis', Antimicrobial agents and chemotherapy, vol. 50, n.º 4, pp. 1552-1554. https://doi.org/10.1128/AAC.50.4.1552-1554.2006

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abstract = "Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.",

author = "Hoeben, {Barbara J.} and Burgess, {David S.} and McConville, {Jason T.} and Najvar, {Laura K.} and Talbert, {Robert L.} and Peters, {Jay I.} and Wiederhold, {Nathan P.} and Frei, {Bradi L.} and Graybill, {John R.} and Rosie Bocanegra and Overhoff, {Kirk A.} and Prapasri Sinswat and Johnston, {Keith P.} and Williams, {Robert O.}",

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doi = "10.1128/AAC.50.4.1552-1554.2006",

language = "English (US)",

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AU - Najvar, Laura K.

AU - Talbert, Robert L.

AU - Peters, Jay I.

AU - Wiederhold, Nathan P.

AU - Frei, Bradi L.

AU - Graybill, John R.

AU - Bocanegra, Rosie

AU - Overhoff, Kirk A.

AU - Sinswat, Prapasri

AU - Johnston, Keith P.

AU - Williams, Robert O.

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AB - Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

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In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

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