In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

Jason Cota; Michael Carden; John R. Graybill; Laura K. Najvar; David S. Burgess; Nathan P. Wiederhold

doi:10.1128/AAC.00538-06

In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

Jason Cota
, Michael Carden
, John R. Graybill
, Laura K. Najvar
, David S. Burgess
, Nathan P. Wiederhold

Department of Pathology

Producción científica: Article › revisión exhaustiva

38 Citas (Scopus)

Resumen

The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC₅₀ values), and IC₉₀ values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

Idioma original	English (US)
Páginas (desde-hasta)	3926-3928
Número de páginas	3
Publicación	Antimicrobial agents and chemotherapy
Volumen	50
N.º	11
DOI	https://doi.org/10.1128/AAC.00538-06
Estado	Published - nov 2006

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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title = "In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility",

abstract = "The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50\% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.",

author = "Jason Cota and Michael Carden and Graybill, \{John R.\} and Najvar, \{Laura K.\} and Burgess, \{David S.\} and Wiederhold, \{Nathan P.\}",

year = "2006",

month = nov,

doi = "10.1128/AAC.00538-06",

language = "English (US)",

volume = "50",

pages = "3926--3928",

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AU - Cota, Jason

AU - Carden, Michael

AU - Graybill, John R.

AU - Najvar, Laura K.

AU - Burgess, David S.

AU - Wiederhold, Nathan P.

PY - 2006/11

Y1 - 2006/11

N2 - The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

AB - The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

UR - https://www.scopus.com/pages/publications/33750577895

UR - https://www.scopus.com/pages/publications/33750577895#tab=citedBy

U2 - 10.1128/AAC.00538-06

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M3 - Article

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SN - 0066-4804

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 11

ER -

In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

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