In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies

Gordon Ramage; Kacy VandeWalle; Stefano P. Bachmann; Brian L. Wickes; José L. López-Ribot

doi:10.1128/AAC.46.11.3634-3636.2002

In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies

Gordon Ramage
, Kacy VandeWalle
, Stefano P. Bachmann
, Brian L. Wickes
, José L. López-Ribot

Department of Microbiology, Immunology & Molecular Genetics

Producción científica: Article › revisión exhaustiva

227 Citas (Scopus)

Resumen

We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

Idioma original	English (US)
Páginas (desde-hasta)	3634-3636
Número de páginas	3
Publicación	Antimicrobial agents and chemotherapy
Volumen	46
N.º	11
DOI	https://doi.org/10.1128/AAC.46.11.3634-3636.2002
Estado	Published - nov 2002

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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abstract = "We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99\% killing at physiological concentrations.",

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AU - Wickes, Brian L.

AU - López-Ribot, José L.

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AB - We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

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In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies

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