TY - JOUR
T1 - in vitro exposure to electromagnetic fields
T2 - Changes in tumour cell properties
AU - Phillips, Jerry L.
AU - Winters, Wendell D.
AU - Rutledge, Loyce
N1 - Funding Information:
These studies were supported in part by grants from the Zachry, HEB, and James R. Dougherty Foundations. Additional support from a research program administered by the New York Department of Health and Health Research, Inc. provided the equipment used for EMF exposure.
PY - 1985
Y1 - 1985
N2 - Two human colon cancer cell lines, Colo 205 and Colo 320 DM, have been studied for their responses to 60 Hz-generated electromagnetic fields (EMF) using soft agar cloning and monoclonal antibody binding assays to assess exposure-induced changes. Cellular responses have been studied after 24 h continuous exposure of cells concurrently to four experimental conditions; i.e. no EMF (E-M-), magnetic field only (M +, 1·0 G rms), electric field only (E +, 300 mA/m2 rms), and combined electric plus magnetic fields at these intensities (E + M +). Under these conditions, both cell lines demonstrated significantly increased colony formation in soft agar and increased expression of tumor associated antigens after exposure to E + M + and to M + as compared to unexposed controls.
AB - Two human colon cancer cell lines, Colo 205 and Colo 320 DM, have been studied for their responses to 60 Hz-generated electromagnetic fields (EMF) using soft agar cloning and monoclonal antibody binding assays to assess exposure-induced changes. Cellular responses have been studied after 24 h continuous exposure of cells concurrently to four experimental conditions; i.e. no EMF (E-M-), magnetic field only (M +, 1·0 G rms), electric field only (E +, 300 mA/m2 rms), and combined electric plus magnetic fields at these intensities (E + M +). Under these conditions, both cell lines demonstrated significantly increased colony formation in soft agar and increased expression of tumor associated antigens after exposure to E + M + and to M + as compared to unexposed controls.
KW - Cell surface properties
KW - Clonogenicity
KW - Electromagnetic fields
KW - Tumour cells
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U2 - 10.1080/09553008514552681
DO - 10.1080/09553008514552681
M3 - Article
C2 - 3485593
AN - SCOPUS:0022654012
SN - 0955-3002
VL - 49
SP - 463
EP - 469
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 3
ER -