The methanolic extract of Hemidesmus indicus (L) R.Br. (Asclepiadaceae) roots was found to inhibit lipid peroxidation and scavenge hydroxyl and superoxide radicals in vitro. The amount required for 50% inhibition of lipid peroxide formation was 217.5μg/ml. The concentrations needed to scavenge hydroxyl and superoxide radicals were 73.5 and 287.5μg/ml, respectively. The intravenous administration of this extract (5mg/kg body weight) in rabbits delayed the plasma recalcification time and enhanced the release of lipoprotein lipase enzyme significantly. The extract also inhibited ADP-induced platelet aggregation in vitro (50-250μg), which was comparable to commercial heparin.
|Idioma original||English (US)|
|Número de páginas||5|
|Publicación||Journal of Ethnopharmacology|
|Estado||Published - ago 1 2003|
|Publicado de forma externa||Sí|
ASJC Scopus subject areas
- Drug Discovery