TY - JOUR
T1 - In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance
AU - Bachmann, Stefano P.
AU - Patterson, Thomas F.
AU - López-Ribot, José L.
PY - 2002
Y1 - 2002
N2 - Caspofungin inhibits the synthesis of 1,3-β-D-glucan, a key step in fungal cell wall biosynthesis. Here we report on its potent in vitro activity (MIC at which 90% of the isolates tested are inhibited = 1 μg per ml of RPMI medium) against 32 Candida albicans fluconazole-susceptible and -resistant clinical isolates irrespective of the underlying resistance mechanism (alterations in ERG11 and/or upregulation of MDR and CDR genes encoding efflux pumps) and provide further evidence that caspofungin is not a substrate for multidrug transporters.
AB - Caspofungin inhibits the synthesis of 1,3-β-D-glucan, a key step in fungal cell wall biosynthesis. Here we report on its potent in vitro activity (MIC at which 90% of the isolates tested are inhibited = 1 μg per ml of RPMI medium) against 32 Candida albicans fluconazole-susceptible and -resistant clinical isolates irrespective of the underlying resistance mechanism (alterations in ERG11 and/or upregulation of MDR and CDR genes encoding efflux pumps) and provide further evidence that caspofungin is not a substrate for multidrug transporters.
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U2 - 10.1128/JCM.40.6.2228-2230.2002
DO - 10.1128/JCM.40.6.2228-2230.2002
M3 - Article
C2 - 12037093
AN - SCOPUS:0036266003
SN - 0095-1137
VL - 40
SP - 2228
EP - 2230
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 6
ER -