Impact of recent pulmonary exacerbations on quality of life in patients with cystic fibrosis

Maria T. Britto, Uma R. Kotagal, Harry D. Atherton, Robert W. Wilmott, Richard W. Hornung, Joel Tsevat

Resultado de la investigación: Articlerevisión exhaustiva

251 Citas (Scopus)


Objective: To compare the health-related quality of life (HRQOL) of people with cystic fibrosis (CF) to the general population, and to determine the relationship between HRQOL and clinical and demographic factors. Design: Cross-sectional analysis of observational cohort. Setting: Outpatient clinics of a Midwestern CF center. Subjects: One hundred sixty-two subjects with CF aged 5 to 45 years. Main outcome measures: Physical and psychosocial summary scores and individual scale scores for the Child Health Questionnaire and Short Form-36. Results: Compared with the general population, people with CF reported similar scores for most psychosocial measures, but lower scores for most physical measures, with the lowest scores on the general health perceptions scale. In multivariable analyses, pulmonary exacerbations in the past 6 months were strongly associated with the physical (p = 0.001) and psychosocial (p = 0.0003) scores. The physical score fell, on average, 6 points per exacerbation and the psychosocial score fell 3 points. Lung function, nutrition, 6-min walk distance, age, gender, and insurance status were not significantly associated with HRQOL in this study population. Those who declined to participate had significantly lower FEV1 percent predicted and nutritional indexes. Our findings may not be generalizable to the entire CF population. Conclusion: Recent pulmonary exacerbations have a profound negative impact on HRQOL that is not explained by differences in lung function, nutritional status, or demographic factors.

Idioma originalEnglish (US)
Páginas (desde-hasta)64-72
Número de páginas9
EstadoPublished - ene. 2002
Publicado de forma externa

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


Profundice en los temas de investigación de 'Impact of recent pulmonary exacerbations on quality of life in patients with cystic fibrosis'. En conjunto forman una huella única.

Citar esto