Immunometabolic alterations in lupus: where do they come from and where do we go from there?

Longhuan Ma, Tracoyia Roach, Laurence Morel

Resultado de la investigación: Review articlerevisión exhaustiva

Resumen

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the overactivation of the immune system has been associated with metabolic alterations. Targeting the altered immunometabolism has been proposed to treat SLE patients based on their results obtained and mouse models of the disease. Here, we review the recent literature to discuss the possible origins of the alterations in the metabolism of immune cells in lupus, the dominant role of mitochondrial defects, technological advances that may move the field forward, as well as how targeting lupus immunometabolism may have therapeutic potential.

Idioma originalEnglish (US)
Número de artículo102245
PublicaciónCurrent Opinion in Immunology
Volumen78
DOI
EstadoPublished - oct 2022

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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