@article{6a1f9e7081554c8bb794300e116c461c,
title = "Immunogenicity of SARS-CoV-2 messenger RNA vaccines in patients with cancer",
abstract = "Patients with cancer experience a higher burden of SARS-CoV-2 infection, disease severity, complications, and mortality, than the general population. SARS-CoV-2 mRNA vaccines are highly effective in the general population; however, few data are available on their efficacy in patients with cancer. Using a prospective cohort, we assessed the seroconversion rates and anti-SARS-CoV-2 spike protein antibody titers following the first and second dose of BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines in patients with cancer in US and Europe from January to April 2021. Among 131 patients, most (94%) achieved seroconversion after receipt of two vaccine doses. Seroconversion rates and antibody titers in patients with hematological malignancy were significantly lower than those with solid tumors. None of the patients with history of anti-CD-20 antibody in the 6 months before vaccination developed antibody response. Antibody titers were highest for clinical surveillance or endocrine therapy groups and lowest for cytotoxic chemotherapy or monoclonal antibody groups.",
keywords = "COVID-19, anti-cancer treatment, antibody, immune response, malignancy, oncology, pandemic, seroconversion, tumor, vaccine",
author = "Alfredo Addeo and Shah, {Pankil K.} and Natacha Bordry and Hudson, {Robert D.} and Brenna Albracht and {Di Marco}, Mariagrazia and Virginia Kaklamani and Dietrich, {Pierre Yves} and Taylor, {Barbara S.} and Simand, {Pierre Francois} and Darpan Patel and Jing Wang and Intidhar Labidi-Galy and Sara Fertani and Leach, {Robin J.} and Jose Sandoval and Ruben Mesa and Kate Lathrop and Nicolas Mach and Shah, {Dimpy P.}",
note = "Funding Information: This project has been funded in whole or in part with federal funds from National Cancer Institute grant P30 CA054174 (Mays Cancer Center at University of Texas Health San Antonio MD Anderson); and grant MRSG-16-152-01-CCE the American Cancer Society and Hope Funds for Cancer Research . A “Research & Development Program” grant from Geneva University Hospitals awarded to N.B. funded part of this study. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. We thank Sebastien Bugeia, Garance Gutknecht, and Anna Battagin from HUG, and the University of Texas Health Biospecimen and Translational Genomics Core Laboratory for support with the enrollment and follow-up of participants and processing of specimens. We also thank Brandon Wing, Nazneen Ali, and Adrian Tan from UTHSA for their health informatic support. Funding Information: This project has been funded in whole or in part with federal funds from National Cancer Institute grant P30 CA054174 (Mays Cancer Center at University of Texas Health San Antonio MD Anderson); and grant MRSG-16-152-01-CCE the American Cancer Society and Hope Funds for Cancer Research. A ?Research & Development Program? grant from Geneva University Hospitals awarded to N.B. funded part of this study. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. We thank Sebastien Bugeia, Garance Gutknecht, and Anna Battagin from HUG, and the University of Texas Health Biospecimen and Translational Genomics Core Laboratory for support with the enrollment and follow-up of participants and processing of specimens. We also thank Brandon Wing, Nazneen Ali, and Adrian Tan from UTHSA for their health informatic support. A.A. P.K.S. and D.P.S. had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. A.A. and P.K.S. contributed equally. K.L. N.M. and D.P.S. are senior authors. Concept and design, A.A. P.K.S. V.K. R.M. R.J.L. K.L. and D.P.S.; acquisition, analysis, or interpretation of data, A.A. P.K.S. R.D.H. N.B. N.M. S.F. P.-F.S. M.D.M. P.-Y.D. B.A. D.P. J.W. R.J.L. K.L. and D.P.S.; statistical analysis, P.K.S. and D.P.S.; drafting of the manuscript, A.A. P.K.S. and D.P.S.; critical revision of the manuscript for important intellectual content, all co-authors; funding acquisition, A.A. N.M. P.D. R.M. and D.P.S.; administrative, technical, or material support, R.D.H. B.A. D.P. J.W. R.J.L. and M.D.M.; supervision, A.A. N.M. P.K.S. J.W. R.J.L. K.L. and D.P.S. A.A. reported receiving personal fees for attending advisory from Bristol-Myers Squibb, AstraZeneca, Roche, Pfizer, Merck Sharp and Dohme, Astella, Eli Lilly, and Boehringer Ingelheim and receiving fees for speaking bureau for Eli Lilly, AstraZeneca, Merck Sharp and Dohme for work performed outside of this study. P.S. reported receiving a grant from the Biomedical Advanced Research and Development Authority outside of this work. I.L.-G. reported receiving personal fees for attending advisory from AstraZeneca. N.M. is a founder and minority shareholder of MaxiVAX SA, a private biotech company based in Geneva, Switzerland, working on personalized cancer immunotherapy and infectious disease vaccines, with no impact on the current manuscript. R.M. reported receiving research support from Celgene, Incyte, Abbvie, Samus, Genotech, Promedior, and CTI; and consulting fees from Novartis, Sierra Onc, LaJolla, and Pharma. D.S. reported receiving a grant from the Biomedical Advanced Research and Development Authority outside of this work. All other co-authors reported no competing interests. We worked to ensure gender balance in the recruitment of study participants. We worked to ensure ethnic or other types of diversity in the recruitment of study participants. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = aug,
day = "9",
doi = "10.1016/j.ccell.2021.06.009",
language = "English (US)",
volume = "39",
pages = "1091--1098.e2",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "8",
}