IL-10通过抑制IFN-γ和IL-2表达促进鼠衣原体感染

Qingzhi He, Mengting He, Xin Wang, Xiaoqing Luo, Yimou Wu, Guangming Zhong

Resultado de la investigación: Articlerevisión exhaustiva

1 Cita (Scopus)

Resumen

Objective: To study the possible molecular mechanism of IL-10 in promoting Chlamydia muridarum infection in mice. Methods: C57BL/6 wild-type and IL-10 gene knockout (IL-10-/-) mice were infected with Chlamydia muridarum. Indirect immunofluorescence assay was used to detect the growth of Chlamydia muridarum in the intestinal and genital tracts. The severity of genital diseases was assessed by hydrosalpinx scoring. Expression of IFN-γ and IL-2 in blood was measured by ELISA. Results: Compared with the wild-type group, Chlamydia clearance in the intestinal and genital tracts of IL-10-/- mice was significantly faster, and the expression of IFN-γ and IL-2 increased significantly. In addition, wild-type mice showed more serious hydrosalpinx. Conclusions: IL-10 delays Chlamydia trachomatis clearance and promotes Chlamydia infection through inhibiting the expression of IFN-γ and IL-2, which aggravates hydrosalpinx.

Título traducido de la contribuciónIL-10 promotes Chlamydia muridarum infection in mice through inhibiting IFN-γ and IL-2 expression
Idioma originalChinese (Traditional)
Páginas (desde-hasta)126-130
Número de páginas5
PublicaciónChinese Journal of Microbiology and Immunology (China)
Volumen39
N.º2
DOI
EstadoPublished - feb. 28 2019

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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