IGF-1 receptor haploinsufficiency leads to age-dependent development of metabolic syndrome

Sachin Thakur, Neha Garg, Ning Zhang, Sophie E. Hussey, Nicolas Musi, Martin L. Adamo

Producción científica: Articlerevisión exhaustiva

4 Citas (Scopus)


Individuals born small for gestational age (SGA) are at a higher risk of developing the metabolic syndrome later in life. IGF-1 resistance has been reported in placentae from SGA births and mutations in the Igf1 receptor gene have been reported in several cohorts of SGA subjects. We have used the Igf1r heterozygous (Igf1r+/-) male mouse as a model to investigate the mechanisms by which Igf1r haploinsufficiency leads to insulin resistance. Despite exhibiting IGF-1 resistance, insulin signaling is enhanced in young Igf1r+/- mice but is attenuated in the muscle of old Igf1r+/- mice. Although smaller than WT (wild type) mice, old-aged Igf1r+/- had increased adiposity and exhibit increased lipogenesis. We hypothesize that IGF-1 resistance initially causes a transient increase in insulin signaling thereby promoting a lipogenic phenotype, which subsequently leads to insulin resistance.

Idioma originalEnglish (US)
Páginas (desde-hasta)937-944
Número de páginas8
PublicaciónBiochemical and Biophysical Research Communications
EstadoPublished - may 13 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry
  • Cell Biology


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