TY - JOUR
T1 - Identification of a qtl for adipocyte volume and of shared genetic effects with aspartate aminotransferase
AU - Bose, Tanushree
AU - Voruganti, V. Saroja
AU - Tejero, M. Elizabeth
AU - Proffit, J. Michael
AU - Cox, Laura A.
AU - VandeBerg, John L.
AU - Mahaney, Michael C.
AU - Rogers, Jeffrey
AU - Freeland-Graves, Jeanne H.
AU - Cole, Shelley A.
AU - Comuzzie, Anthony G.
N1 - Funding Information:
Acknowledgments This investigation was conducted in part in facilities constructed with support from the Research Facilities Improvement Program under grants C06 RR014578, C06 RR013556, C06 RR015456, and C06 RR017515 and with support from NIH grants PO1 HL028972, P51 RR013986, and R01 MH59490, as well as research support from the Kronkosky Charitable Foundation.
PY - 2010/6
Y1 - 2010/6
N2 - Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST.
AB - Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST.
KW - Adipocyte size
KW - Aspartate aminotransferase
KW - Genome scan
KW - Nonalcoholic fatty liver disease
KW - Obesity
KW - Qtl
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U2 - 10.1007/s10528-010-9337-0
DO - 10.1007/s10528-010-9337-0
M3 - Article
C2 - 20390338
AN - SCOPUS:77953130367
VL - 48
SP - 538
EP - 547
JO - Biochemical Genetics
JF - Biochemical Genetics
SN - 0006-2928
IS - 5-6
ER -