Hypoxia in astrocytic tumors and implications for therapy

David A. Cavazos, Andrew J. Brenner

Producción científica: Review articlerevisión exhaustiva

27 Citas (Scopus)


Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved.

Idioma originalEnglish (US)
Páginas (desde-hasta)227-233
Número de páginas7
PublicaciónNeurobiology of Disease
EstadoPublished - ene 1 2016

ASJC Scopus subject areas

  • Neurology


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