TY - JOUR
T1 - Hydroxyapatite as an active ingredient in oral care
T2 - an international symposium report
AU - Pawinska, Malgorzata
AU - Paszynska, Elzbieta
AU - Limeback, Hardy
AU - Amaechi, Bennett T.
AU - Fabritius, Helge Otto
AU - Ganss, Bernhard
AU - O’Hagan-Wong, Kelsey
AU - Wiesche, Erik Schulze zur
AU - Meyer, Frederic
AU - Enax, Joachim
N1 - Publisher Copyright:
© 2023 ICE Publishing. All rights reserved.
PY - 2023/12/6
Y1 - 2023/12/6
N2 - Hydroxyapatite, Ca5(PO4)3(OH), is a bioinspired active ingredient for preventive oral health care. The use of hydroxyapatite in the prevention of oral diseases has gained interest, particularly in recent years. Hydroxyapatite can be used in office and for daily oral care (e.g. in toothpastes and mouthwashes). The first clinical efficacy studies on caries prevention and reduction of symptoms of dentin hypersensitivity were conducted in the 1980s. These were followed by various in vitro and in situ studies and several more recent clinical trials. A number of systematic reviews and meta-analyses on the use of hydroxyapatite in preventing oral health problems have been published. Summarizing these data, hydroxyapatite is a versatile active ingredient with multiple benefits that include caries prevention, relief from dentin hypersensitivity and tooth whitening. Since this calcium phosphate mineral has an excellent biocompatibility, it is safe for all patient groups. This interdisciplinary review gives an overview of the developments in hydroxyapatite research, highlights the research progress made regarding hydroxyapatite as a biomimetic active ingredient and summarizes the state-of-the-art evidence in support of hydroxyapatite efficacy.
AB - Hydroxyapatite, Ca5(PO4)3(OH), is a bioinspired active ingredient for preventive oral health care. The use of hydroxyapatite in the prevention of oral diseases has gained interest, particularly in recent years. Hydroxyapatite can be used in office and for daily oral care (e.g. in toothpastes and mouthwashes). The first clinical efficacy studies on caries prevention and reduction of symptoms of dentin hypersensitivity were conducted in the 1980s. These were followed by various in vitro and in situ studies and several more recent clinical trials. A number of systematic reviews and meta-analyses on the use of hydroxyapatite in preventing oral health problems have been published. Summarizing these data, hydroxyapatite is a versatile active ingredient with multiple benefits that include caries prevention, relief from dentin hypersensitivity and tooth whitening. Since this calcium phosphate mineral has an excellent biocompatibility, it is safe for all patient groups. This interdisciplinary review gives an overview of the developments in hydroxyapatite research, highlights the research progress made regarding hydroxyapatite as a biomimetic active ingredient and summarizes the state-of-the-art evidence in support of hydroxyapatite efficacy.
KW - bioinspired
KW - biomimetic materials
KW - bionics
KW - caries
KW - clinical study
KW - hydroxyapatite
KW - modes of action
KW - oral care
KW - teeth
KW - toothpaste
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UR - http://www.scopus.com/inward/citedby.url?scp=85180959398&partnerID=8YFLogxK
U2 - 10.1680/jbibn.23.00034
DO - 10.1680/jbibn.23.00034
M3 - Article
AN - SCOPUS:85180959398
SN - 2045-9858
VL - 13
SP - 1
EP - 14
JO - Bioinspired, Biomimetic and Nanobiomaterials
JF - Bioinspired, Biomimetic and Nanobiomaterials
IS - 1
ER -