Human variants of O6-alkylguanine-DNA alkyltransferase

Anthony E. Pegg, Qingming Fang, Natalia A. Loktionova

Producción científica: Review articlerevisión exhaustiva

59 Citas (Scopus)


This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O6-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy.

Idioma originalEnglish (US)
Páginas (desde-hasta)1071-1078
Número de páginas8
PublicaciónDNA Repair
EstadoPublished - ago 1 2007
Publicado de forma externa

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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