TY - JOUR
T1 - Human leukocyte antigen associations in basal cell carcinoma
AU - Myskowski, Patricia L.
AU - Pollack, Marilyn S.
AU - Schorr, Ethlynn
AU - Dupont, Bo
AU - Safai, Bijan
N1 - Funding Information:
From the Dermatology Service, Department of Medicine, and Im-munogenetic Laboratories, Memorial Sloan-Kettering Cancer Center. Supported in part by the American Cancer Society Junior Faculty Clinical Fellowship No. 675, R. S. Sinn., Mirsky, Dickson and Chesebrough-Pond's, Inc. Accepted for publication Dec. 20, 1984. Reprint requests to: Dr. Patricia L. Myskowski, 1275 York Ave., New York, NY 10021.
PY - 1985
Y1 - 1985
N2 - Basal cell carcinoma is the most common form of skin cancer and is one in which both host and environmental factors are thought to play a role in its pathogenesis. For an investigation of the role of human leukocyte antigen (HLA)-associated variations in genetic susceptibility, thirty-one patients with multiple basal cell carcinomas were typed for HLA-A, B, C, and DR antigens. Patients were compared with both local and appropriate ethnic group controls. No statistically significant association with HLA-A, B, or C antigens was noted in any group. However, a significant increase in HLA-DR1 was noted in non-Irish, non-Ashkenazi patients. A tendency toward a decrease in HLA-DR3 was also noted among patients of Irish or Ashkenazi Jewish descent. The role of HLA-associated genetic factors in this form of skin cancer needs further investigation.
AB - Basal cell carcinoma is the most common form of skin cancer and is one in which both host and environmental factors are thought to play a role in its pathogenesis. For an investigation of the role of human leukocyte antigen (HLA)-associated variations in genetic susceptibility, thirty-one patients with multiple basal cell carcinomas were typed for HLA-A, B, C, and DR antigens. Patients were compared with both local and appropriate ethnic group controls. No statistically significant association with HLA-A, B, or C antigens was noted in any group. However, a significant increase in HLA-DR1 was noted in non-Irish, non-Ashkenazi patients. A tendency toward a decrease in HLA-DR3 was also noted among patients of Irish or Ashkenazi Jewish descent. The role of HLA-associated genetic factors in this form of skin cancer needs further investigation.
UR - http://www.scopus.com/inward/record.url?scp=0021823858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021823858&partnerID=8YFLogxK
U2 - 10.1016/S0190-9622(85)70127-2
DO - 10.1016/S0190-9622(85)70127-2
M3 - Article
AN - SCOPUS:0021823858
SN - 0190-9622
VL - 12
SP - 997
EP - 1000
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -