Human apolipoprotein A-I and C-III genes reside in the p11 → q13 region of chromosome 11

Apolipoprotein (apo) A-1 is a major protein of high density lipoproteins (HDL). The gene for apoA-I has been localized to the p11 → q13 region of chromosome 11 by filter hybridization analysis of mouse-human hybrid cell cDNAs containing chromosome 11 translocations utilizing a cloned human apoA-I cDNA probe. The known linkage of apoA-I and apoC-III also permitted the simultaneous assignment of the apoC-III gene to the same region on chromosome 11. Comparison with previously established gene linkages on the mouse and human genome suggests that apoA-I + apoC-III may be linked to the esterase A4 and uroporphyrinogen synthase genes which are present on the long arm of human chromosome 11. The localization of the apoA-I + apoC-III genes in the p11 → q13 region of chromosome 11 represents a definitive chromosomal assignment of a human apolipoprotein gene, and will now anable more detailed analysis of the geneomic organization and linkages of the apolipoprotein genes.