Human APOBEC3 proteins, retrovirus restriction and HIV drug resistance

Guylaine Haché, Louis M. Mansky, Reuben S. Harris

Producción científica: Review articlerevisión exhaustiva

48 Citas (Scopus)

Resumen

Over 40 million people worldwide currently have HIV/AIDS. Many antiretroviral drugs have proven effective, but drug-resistant HIV variants frequently emerge to thwart treatment efforts. Reverse transcription errors undoubtedly contribute to drug resistance, but additional significant sources of viral genetic variation are debatable. The human APOBEC3F and APOBEC3G proteins can potently inhibit retrovirus infection by a mechanism that involves retroviral cDNA cytosine deamination. Here we review the current knowledge on the mechanism of APOBEC3-dependent retrovirus restriction and discuss whether this innate host-defense system actively contributes to HIV genetic, variation.

Idioma originalEnglish (US)
Páginas (desde-hasta)148-157
Número de páginas10
PublicaciónAIDS Reviews
Volumen8
N.º3
EstadoPublished - jul 2006
Publicado de forma externa

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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