Hodgkin-Huxley Models

Most theoretical and computational studies of neuronal function are based on a model for action potential generation developed more than 50, years ago by AL Hodgkin and AF Huxley. In this article, we review the historical and biophysical context that surrounded the creation of this model. We describe the fundamental properties of the Hodgkin and Huxley model, emphasizing its capability to replicate experimental results which it was not explicitly built to account for. Finally, we compare the original and modern physical interpretations of the model and briefly discuss its limitations and other alternative models.