HLA Genotyping in Family Members and Patients with Familial Polycystic Ovarian Disease

Fred P. Mandel, R. Jeffrey Chang, B. Dupont, Marilyn S. Pollack, Lenore S. Levine, Maria I. New, John K.H. Lu, Howard L. Judd

Resultado de la investigación: Articlerevisión exhaustiva

16 Citas (Scopus)

Resumen

To determine whether the familial occurrence of polycystic ovarian disease (PCO) is related to the major histocompatibility complex (HLA), four families in whom at least two siblings had clinical evidence of disease were examined. The diagnosis of PCO was confirmed by increased serum testosterone, androstenedione, and LH levels compared to those in normal women. Elevated concentrations of dehydroepiandrosterone sulfate indicated excess adrenal androgen secretion. The result of HLA genotyping in the families studied demonstrate that PCO does not exhibit linkage to the HLA system.

Idioma originalEnglish (US)
Páginas (desde-hasta)862-864
Número de páginas3
PublicaciónJournal of Clinical Endocrinology and Metabolism
Volumen56
N.º4
DOI
EstadoPublished - abr. 1983
Publicado de forma externa

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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