@article{6968acfeaee540349123fb6417c88677,
title = "Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort*",
abstract = "Introduction: We investigated cross-sectional associations between the Dietary Inflammatory Index (DII) and measures of brain volume and cerebral small vessel disease among participants of the Framingham Heart Study Offspring cohort. Methods: A total of 1897 participants (mean ± standard deviation, age 62±9) completed Food Frequency Questionnaires and brain magnetic resonance imaging (MRI). Results: Higher (pro-inflammatory) DII scores, averaged across a maximum of three time points, were associated with smaller total brain volume (beta ± standard error: –0.16 ± 0.03; P <.0001) after adjustment for demographic, clinical, and lifestyle covariates. In addition, higher DII scores were associated with smaller total gray matter volume (–0.08 ± 0.03; P =.003) and larger lateral ventricular volume (0.04 ± 0.02; P =.03). No associations were observed with other brain MRI measures. Discussion: Our findings showed associations between higher DII scores and global brain MRI measures. As we are one of the first groups to report on the associations between higher DII scores and brain volume, replication is needed to confirm our findings.",
keywords = "Framingham Heart Study, apolipoprotein E ε4, brain volume, cerebral microbleeds, inflammatory diet, silent brain infarcts",
author = "{Melo Van Lent}, Debora and Hannah Gokingco and Short, {Meghan I.} and Changzheng Yuan and Jacques, {Paul F.} and Romero, {Jos{\'e} R.} and DeCarli, {Charles S.} and Beiser, {Alexa S.} and Sudha Seshadri and Himali, {Jayandra J.} and Jacob, {Mini E.}",
note = "Funding Information: We thank the FHS participants for donating their time to our research. The Framingham Heart Study was supported by the National Heart, Lung, and Blood Institute (contract no. N01‐ HC‐25195, HHSN268201500001I, and no. 75N92019D00031); and the National Institute on Aging (NIA; R01 AG054076, R01 AG049607, R01 AG033193, U01 AG049505, U01 AG052409, U01 AG058589, RF1 AG059421); and by grants from the National Institute of Neurological Disorders and Stroke (NS017950 and UH2 NS100605). Dr. Melo van Lent received funding provided by the NIH‐NIA (R03 AG067062‐01) and the ASPEN Rhoads Research foundation (C. Richard Fleming grant and Daniel H. Teitelbaum grant) to support this research project. In addition, she is supported by NIH‐NIA P30 AG066546; Funds from the USDA Agricultural Research Service Agreement (No. 58‐8050‐9‐004) supported in part the collection of dietary data for this project and the efforts of Dr. Paul Jacques; Dr. DeCarli received funding from NIH‐NIA (P30 AG0101029); Dr. Sudha Seshadri is supported by grants from the NIH‐NIA (P30 AG066546 and R01 AG059421); Dr. Jayandra J. Himali is supported by a grant from the NIH‐NIA (R01 AG062531). The funding agencies had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. Funding Information: We thank the FHS participants for donating their time to our research. The Framingham Heart Study was supported by the National Heart, Lung, and Blood Institute (contract no. N01- HC-25195, HHSN268201500001I, and no. 75N92019D00031); and the National Institute on Aging (NIA; R01 AG054076, R01 AG049607, R01 AG033193, U01 AG049505, U01 AG052409, U01 AG058589, RF1 AG059421); and by grants from the National Institute of Neurological Disorders and Stroke (NS017950 and UH2 NS100605). Dr. Melo van Lent received funding provided by the NIH-NIA (R03 AG067062-01) and the ASPEN Rhoads Research foundation (C. Richard Fleming grant and Daniel H. Teitelbaum grant) to support this research project. In addition, she is supported by NIH-NIA P30 AG066546; Funds from the USDA Agricultural Research Service Agreement (No. 58-8050-9-004) supported in part the collection of dietary data for this project and the efforts of Dr. Paul Jacques; Dr. DeCarli received funding from NIH-NIA (P30 AG0101029); Dr. Sudha Seshadri is supported by grants from the NIH-NIA (P30 AG066546 and R01 AG059421); Dr. Jayandra J. Himali is supported by a grant from the NIH-NIA (R01 AG062531). The funding agencies had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2022 the Alzheimer's Association.",
year = "2023",
month = feb,
doi = "10.1002/alz.12685",
language = "English (US)",
volume = "19",
pages = "621--631",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "2",
}