Hidden in plain sight: urinary Cryptococcus neoformans missed by routine diagnostics in a patient with acute leukemia

Zoe F. Weiss, James E. DiCarlo, David W. Basta, Stephanie Kent, Alexis Liakos, Lindsey Baden, Manfred Brigl, Sanjat Kanjilal, Connie Cañete-Gibas, Nathan P. Wiederhold, Sankha S. Basu

Producción científica: Articlerevisión exhaustiva

Resumen

Cryptococcuria is a rare manifestation of localized cryptococcal disease. We present a case of Cryptococcus neoformans urinary tract infection in an immunocompromised host missed by routine laboratory workup. The patient had negative blood cultures, a negative serum cryptococcal antigen (CrAg), and “non-Candida yeast” growing in urine culture that was initially dismissed as non-pathogenic. The diagnosis was ultimately made by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) from a repeat urine culture after transfer to a tertiary care center. Cryptococcus should be considered in the differential of refractory urinary tract infections growing non-Candida yeast.

Idioma originalEnglish (US)
Número de artículo49
PublicaciónAnnals of Clinical Microbiology and Antimicrobials
Volumen21
N.º1
DOI
EstadoPublished - dic 2022

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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