Heteromeric connexons in lens gap junction channels

Jean X. Jiang, Daniel A. Goodenough

Resultado de la investigación: Articlerevisión exhaustiva

230 Citas (Scopus)


Gap junction channels are formed by paired oligomeric membrane hemichannels called connexons, which are composed of proteins of the connexin family. Experiments with transfected cell lines and paired Xenopus oocytes have demonstrated that heterotypic intercellular channels which are formed by two connexons, each composed of a different connexin, can selectively occur. Studies by Stauffer [Stauffer, K. A. (1995) J. Biol. Chem. 270, 6768-6772] have shown that recombinant Cx26 and Cx32 coinfected into insect cells may form heteromeric connexons. By solubilizing and subfractionating individual connexons from ovine lenses, we show by immunoprecipitation that connexons can contain two different connexins forming heteromeric assemblies in vivo.

Idioma originalEnglish (US)
Páginas (desde-hasta)1287-1291
Número de páginas5
PublicaciónProceedings of the National Academy of Sciences of the United States of America
EstadoPublished - feb 6 1996
Publicado de forma externa

ASJC Scopus subject areas

  • General


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